SCI写作高大上句型1000例—101‐200
101、The activation of …. in response to….. signalling is required for….., and the results
presented above suggest that ….. is a component of this signaling cascade
102、To test this hypothesis, we performed….. This feature might explain the fact that
103、In vivo experiments suggest that ….This is supported by the fact that depletion
of….with the aid of RNA interference (RNAi) attenuates Rho activation in response
to …To further explore the mechanism of …. function, we examined the interactions
between…..and ,…..
104、To investigate the function of….
105、We tested this prediction by analyzing….
106、Several studies have demonstrated that …..pathway controls…… during ….
development, and that activation of……. is an indispensable step in this process
107、This difference may reflect the fact that……common but variant molecular
mechanism may be involved in
108、Five lines of evidence indicate that……. led us to predict and verify that……
109、It will be interesting to investigate whether ….. has an importantfunction in this
process.
110、…..used as a traditional Chinese medicine for centuries, offers therapeutic
potential for cardiovascular and other diseases. …….., extracted from the root extract
of rhubarb has sparked increasing interest for therapeutic application.
111、It was postulated that…. Therefore the present study was designed to study the
effect of….on VSMCs proliferation induced by Ang II, and the expression of….
112、…. has been implicated in…. underlining its importance in cardiovascular disease
113、XXX provided a possible avenue for interference with VSMCs proliferation….
114、The major finding of this work showed that….
115、The present study provided a valuable novel insight into molecular mechanisms
of ….inhibited VSMCs proliferation induced by …….
1 116、To verify that emodin mediated effects on VSMCs were not a consequence of
cytotoxicity, LDH activity was determined as a parameter of cytotoxicity in
supernatants of emodin and Ang II‐treated cells. Consistent with the light microscope
observations, LDH activity in supernatants of treated and untreated cells remained
unchanged. So the inhibitory effect was mainly due to an inhibition of cell proliferation
rather than to a direct cytotoxic effect.
117 、 Further evidence was provided that ….played a crucial role in the
cardioprotective properties of …..
118、 The present study was undertaken to elucidate the effect of the …. and …. in
combination on XXX. The present studies were undertaken to investigate the potential
effect of…. and to explore the cellular mechanism of cross‐talk of the AT1 receptor and
statin in vascular smooth muscle cells (VSMCs).
119、The present study explored the possibility that…..
120、Collectively, these facts and speculations suggest that …
121、In order to ascertain a causal relationship between
122、Unfortunately, we could not completely exclude the involvement of
123、Collectively, these facts and speculations suggest that …
124、Although molecular mechanisms involved in … have not been fully clarified, …
125、In summary, the present study demonstrates that …
126．in our conditions we could not rule out a possible involvement of this … in
mediating …
127、In support of this hypothesis, it has been shown that…..
128、 This potentiation effect indirectly suggests that each agonist uses a different
signaling pathway
129 、 Most likely this is due to an accumulative effect of both drugs
inhibiting ……activity.
130、 It is tempting to speculate that the beneficial effect of…may also be due to inhibition of…..
131、 The relevance and the exact mechanisms by which aspirin affects SR‐BI, CD36
and ABCA1 in vitro remain to be determined, as does the role of CD36 expression in
antiatherogenic conditions.
132、In the present study, first, we investigated the expression of PPARs in BAEC, and
subsequently, examined whether PPAR activators modify TNF‐a‐and PMA‐induced
LOX‐1 expression in cultured BAEC.
133、Our results do not allow us to exclude the participation of such mechanisms in
the downregulation of
134、Although the potential roles of this receptor in atherogenesis are not yet fully
understood, it has been suggested that
135、In the current study, we investigated the effect of….
136、In the last decade, it was recognized that … play a pivotal role in both early and
late atherogenesis
137、…..are fundamental ‘players’ in atherogenesis since they change the properties
of different cells involved in atherosclerosis and thrombosis
138、This review elucidates the major aspects concerning….
139、Interestingly, in vitro and in vivo studies have revealed that…..
140、The predominant function of ….in atherosclerotic lesion formation is thought to
be activation of ……
141、As we and others have reported,…. …….were the first to show in vivo that…
142、Recent reports have established SMCs as a major player in the initiation of the
atherosclerotic process in addition to their role in thrombus formation after plaque
rupture in late atherosclerosis.
143、In fact, there is increasing evidence that….
144、Although it is not fully clear which receptor is responsible for the binding of native
lipoproteins, some data indicate that…
145、The emerging concept that….
146 、 It is well known that…However, there are different opinions
concerning…Furthermore, it is still not sufficiently elucidated whether…
147、In an earlier study we showed that…. Especially noteworthy is that..
148、The expression pattern and role of…..in SMC is still not clear.
149、In this study, we focused on …..expression by SMC in atherosclerotic lesions and
the effects of different cytokines on….expression in cultured AoSMC, as well as uptake
of oxLDL in these cells.
150、Several mechanisms have been proposed to explain the … effect on….
151、we are currently investigating in our laboratory whether these pathways are implicated in….
152 、 To the best of our knowledge, this is the first evidence that …..may affect ….through the modulation of…..
153、The experiments with ……confirmed the central role played by ….. in controlling….
154、So far, our study shows that…..
155 、 The mechanism by which……may affect RhoA activity is currently under investigation in our laboratory.
156、In summary, our results suggest that……On the other hand, our study suggests that….
157、Although that difference did not reach statistical significance, a certain trend was noted.
158、Moreover, we have observed that simvastatin impaired NF‐kB binding activity more intensively than a concentration of XXX. Preincubation with the antioxidant PDTC (200 mmol/L) also reduced NF‐kB activity
159、To test whether NF‐kB binding activity increment was due to intracellular XXX, VSMC were preincubated with Tiron, a membrane‐permeable non enzymatic XXX scavenger…..
160、To study the implication of….. in…… activation elicited by….., ….. cells were incubated with SB 20358 (p38 kinase specific inhibitor) and PD 98059 (p42/44 specific inhibitor) 1 hour prior to….
161、In this work we have demonstrated that lipophilic HMG‐CoA reductase inhibitors, atorvastatin and simvastatin, interfere with the…… signaling pathway stimulated by …...
162、Several authors have already proposed that statins may possess antioxidant propertiesin vitro and in vivo,,,,,,
163、In recent years, accumulating evidence have demonstrated the pleiotropic effects of HMG‐CoA reductase inhibitors including antiinflammatory effects. In this regard, we have previously shown that pretreatment of ……cells with…. reduced the …. binding activity elicited by proinflammatory agents such as ……..
164、Several indirect lines of evidence suggest a role for…..
165、To understand the mechanisms implicated in NF‐kB inhibition by statins, we first investigated the effect of statins on….. levels. We have shown that the pretreatment of,,,,,,,, with ……. Prevents…… Accordingly, several authors have demonstrated that……
166、Along these lines, we and others have shown that……
167 、 however, the mechanisms by which the inhibition of……. led to the stabilization…….remain to be elucidated.
168、Contradictory results have been reported because it has been shown that….
169、….have spawned a wide variety of clinically useful inhibitors collectively referred to as ‘statins’.
170、….has been docu‐mented in numerous studies
171、Recent in vitro and in vivo evidence suggests that…. however, the mechanisms responsible have only recently begun to come to light.
172、This work is significant in that it demonstrates for the first time…
173、The present study describes the characterization of……. holds great promise for the use of statins to treat…..
174、This discrepancy has invited speculation regarding other activities of these drugs
175、..has recently become recognized as a central player in a variety of cellular events including……
176、The functional significance of this activity is demonstrated by observations that..
Other recent studies support this finding, demonstrating that…
177、The development of…has been a major milestone in the primary and secondary prevention of coronary heart disease.
178、It has been recently proposed that….. These agents, besides…. have a multitude of other effects, which may have a bearing on the cardioprotective effect of these agents
179、The present study was designed to examine the following hypotheses: (a)；(b); (c)
180、There appears to be general agreementthat….
181、A number of excellent reviews are available with regard to the current views on atherogenesis
182、This is consonant with the fact that….
183、There is an abundant amount of epidemiological evidence indicating that…
184、It is generally supposed that the active constituents contributing to these protective effects are anti‐oxidant….
185、There has been a growing interest in exploring the health advantages of …in recent years
186、In order to explore the capacity of free radical scavenging/quenching of….
187 、 The data were quantitatively assessed by…. However, it remains to be established whether,,,,,
188、The aim of this investigation is to measure the effect of……in general on…
189、Further experiments in animal model of anti‐atherosclerotic activities and pharmacological properties and the mechanisms of natural dieting components of ….are needed.
190、……is a hallmark and key event of early atherogenesis
191、Several studies have strongly implicated activation of ….in the pathogenesis of ……
192、Interestingly enough, our data unmask an antiatherosclerotic effect of …….
193、Of particular interest is the fact that in our study ………
194、the present findings suggest a role for….. in atherogenesis……and anticipate the application of……_ inhibitors as putative antiatherosclerotic drugs.
195、…prompt us to hypothesize that…..
196、Therefore, it is interesting to hypothesize that
197、Recently, we have shown the presence of。。。
198、Future experiments should address the question to what extent both activation and inhibition of NF‐kB affectthe process of atherogenesis。。。。
199、One of the most important atheroprotective roles of HDL is reverse cholesterol
transport, in which excess cholesterol in macrophage foam cells undergoes efflux and then is transported to the liver for excretion in the bile
200、Therefore, more research is warranted to determine the role of ….. in the pathophysiology of cardiovascular disease.
sci谜案集第六部 sci是什么 sci二区和三区区别
