SCI写作高大上句型1000例—201‐300
201、represent a promising alternative for the future because of…..
202、We investigated the association between …
203、Using data from the ….. which assessed the impact of…… we sought to explore
potential mechanisms underlying this adverse outcome
204、The mainstay of treatment for AS remains pharmacological; however, catheter
ablation has increasingly been used over the last decade. The relative merits of each
strategy have not been extensively studied.
205、Despite favorable effects on high‐density lipoprotein cholesterol (HDL‐C) and low‐
density lipoprotein cholesterol, the cholesteryl ester transfer protein inhibitor
torcetrapib failed to slow atherosclerosis progression and increased mortality. We
investigated the relationship between lipid changes and progression of coronary
atherosclerosis.
206、Future studies with …….inhibitors without off‐target toxicity are needed to settle
this issue
207、This study is the first to examine the effect of direct……..stimulation on…..with
the use of the novel …..receptor agonist compound 21
208、Treatment with….. was assessed by……were analyzed for inflammation and
apoptosis with immunoblotting and real‐time reverse transcription polymerase chain
reaction….. significantly improved….. In regard to underlying
mechanisms, …diminished…. indicating an antiapoptotic effect. Phosphorylation of
the p44/42 and p38 mitogen‐activated protein kinases, both involved in the regulation
of cell survival, was strongly reduced after MI but almost completely rescued by C21
treatment. Furthermore,….decreased ……..as well as cardiac interleukin‐6, interleukin‐
1β, and interleukin‐2 expression, suggesting an antiinflammatory effect.
209、Direct…… stimulation may be a novel therapeutic approach to improve …… by
antiapoptotic and antiinflammatory mechanisms.
1 210、However, its underlying mechanism of anti‐adipogenic effects remains unknown
211、New research efforts have begun to explore the potential utility of PPARγ
antagonists to deliver therapeutic benefit with reduced side‐effect profiles…..
212、To examine whether the observed effect of Tan in the suppression of …… was
mediated through the PPARγ pathway
213、thus it is reasonable to postulate that….. However, the possible effects of Tan
on other tissues await further investigation.
214、The study warrants further investigation to explore therapeutic potential of Tan
in metabolic Disorders.
215、...to this end….
216、Experimental and clinical data indicate that statins may confer cardiovascular
benefits in addition to the lipid lowering activity at least partly by modulating the
inflammatory arm of atherosclerosis. We therefore examined the ability of statins to
modulate ….expression in….. by analyzing the effect of simvastatin (20 mg qd) and
atorvastatin (80 mg qd) on .. expression
217、In the present study, we show disturbed regulation of the homeostatic
218、Although several additional experiments will have to be performed, based on
recent studies, it is tempting to hypothesize that the different expression pattern of
XXX
219、The findings in the present study suggest that these molecules also could be
involved in the XXX
220、If such mechanisms also are operating withinthe atherosclerotic lesion, they may
in addition to promoting an inflammatory Th1 phenotype, also induce a matrix
degrading, inflammatory, and prothrombotic phenotype
221、…..are known to have persistently increased …levels……our finding could be of
relevance also in relation to……further supporting such a notion
222、However, 2 very recent articles have suggested that …. may play an important
2 role in emigration of T‐cells from inflamed tissue with particularly pronounced effect
on…..
223、by …., and by ……inducing a matrix degrading, prothrombotic, and inflammatory
phenotype in macrophages, these chemokines could contribute to atherogenesis and
plaque destabilization, possibly representing novel targets for therapy in CAD
224、Recent studies suggest that the beneficial effects of statins in atherosclerotic
disorders may be related to their immunomodulatoryproperties. Herein we show that
these drugs are able to….
225、To further elucidate this issue, we examined….. To further characterize…..
226、Evidence from clinical and experimental studies supports a pathogenic role for
inflammation in atherosclerosis. This increasing appreciation of the importance of
inflammation in atherogenesis has focused attention on molecules that direct…..
227、We performed studies in patientswith ….and healthy controls, in vitro studies in
T‐cells and macrophages, and studies in apolipoprotein‐E–deficient (ApoE–/–) mice
and human atherosclerotic carotid plaques…..
228、The advent of (HMG‐CoA) reductase inhibitors, or statins, has revolutionized the
treatment of hypercholesterolemia due to competitive inhibition of HMG‐CoA
reductase, the rate‐limiting enzyme that catalyzes the de novo cholesterol biosynthesis.
In addition a growing body of evidence suggests that statins exert beneficial vascular
effects that are independent of their cholesterol‐lowering potencies
229、The mechanisms underlying these serum lipid‐independent effects of statins are
not completely understood, but there is increasing evidence that….
230、….in the development of atherosclerosis is still undergoing debate
231、Therefore, the aim of this study was to evaluate whether the statin‐induced
increase…Previously, we demonstrated that….
232、Thus, conflicting results are available for these mouse models of atherosclerosis
regarding the effects of statins on atherogenesis….
3 233、To the best of our knowledge the effect of statins on atherogenesis in apoE/LDLR‐
deficient mice has not been studied. Thus, the aim of this study was to evaluate
whether atorvastatin possesses hypolipidemic and anti‐inflammatory effects in these
mice. We analyzed lipid profile and inflammatory markers in blood and together with
expression of inflammatory markers and lesion size in the blood vessel wall.
234、but studies investigating the potentially additive effects of a combined treatment
strategy are rare. We hypothesised that……
235、However, the mechanisms for its regulation remain elusive……
236、revealing Lp‐PLA2 as an exciting new drug target for the prevention of serious
cardiovascular disease. …
237 、 This study provides compelling evidence that inhibition of…..blocks the
development of unstable plaques by reducing the generation of pro‐inflammatory
lipids.
238、The concept that atherosclerosis is a chronic inflammatory disease has now
gained wide acceptance in the field of cardiovascular research.
239、Despite the accumulating circumstantial evidence pointing to …….as a culprit in
unstable
plaque formation, definitive proof has been lacking….
240、….an effect that was completely abrogated in the darapladib‐treated group
241、What remains to be established is whether selective inhibition of …… reduces
vulnerable plaque formation in humans and, ultimately, the incidence of heart attack
and stroke.
242、These increases were significantly reduced in a dose dependent manner by co‐
treatment with…… No cytotoxic effects of …… were observed under the same
experimental conditions as assessed by lactate dehydrogenase release and MTT assay.
243、Several epidemiological studies and intervention trials have been performed
with …..and some of them showed that it prevents atherosclerosis
4 244、…..was assumed to act by…. However, at the cellular level, …. acts by inhibition
Of…..
245、Recent research revealed that these effects are not the result of the antioxidant
activity of ….., but rather of precise molecular actions of this compound. It is assumed
that specific interactions of …..are at the basis of its non‐antioxidant effects
246、…..modulates the expression of genes that are involved in atherosclerosis (e.g.
scavenger receptors, integrins, selectins, cytokines, cyclins). These interactions
promise to reveal the biological properties of vitamin E and allow designing better
strategies for the protection against atherosclerosis progression
247、Alternative non‐antioxidant mechanisms of TSN action have been recently
suggested, such as its involvement in cellular signalling, interference with enzymatic
activity, apoptosis and gene expression modulation
248、is an important cause of mortality and morbidity late after myocardial infarction….
are often poorly defined.
249、.. have not been investigated. ….. The prevalence and prognostic significance of ….
are poorly understood.
250、The study of ……..could offer insights into primary and secondary prevention
251、We established…. Morphological examinations by autopsy or brain imaging were
performed on….. The present article aims to provide accurate estimates of the
prevalence, awareness, treatment, and control of hypertension
252 、 Although heat shock protein 60 is implicated in the pathogenesis of
atherosclerosis, its role in coronary heart disease is uncertain. This study explored the
influence of circulating Hsp60 on CHD in a large case‐control study, as well as the
impact of acute myocardial infarction on Hsp60 levels in a prospective study.
253、….is associated with an increased risk of cardiovascular disease (CVD); however,
there have been few well‐designed prospective studies of this issue in…. Recent
epidemiological studies have suggested that….
5 254、These molecules have facilitated the understanding of both……
255、These interesting in vitro data on the effects of activation of the LOX‐1 receptor
prompted us to investigate the role of LOX‐1 and OxLDL in vivo by means of a…
256、to obtain….we used….assuming that….to verify whether….to further investigate
the effect of ……on….to examine whether…..to determine the effects of.. on….to
examine the physiological consequences of ……
257、However, the in vivo function of LOX‐1 has yet to be determined…..
258、There are 3 reasonable interpretations of the present results. First, second,
third, ….
259、…..did not reach a statistically significant difference between the apoEKO and
LOXtg/apoEKO strains.
260、This is in good agreement with ….. further supports a role for LOX‐1 in the current
model of atherogenesis…..
261、This needs to be considered in interpreting the data in the present study.
262、Based on the data from experimental animal models including the present study,
it is possible that…
263、Recently, other researchers along with our laboratory have reported that…..
264、Although these studies were not able to specify whether the….. specifically
enhances the activity of LOX‐1, together with the data reported here, there is support
for a pro‐atherogenic effect of LOX‐1 in humans.
265、…..should prove to be a useful model for further investigation into the initiation
and progression of atheromatous changes in the mouse heart
266、We were surprised to find a significant and consistent change in the mRNA
expression profile under the various conditions
267、To characterize the role of…
268、These results are in agreement with our findings reported previously in ….. cells
269、This phenomenon can be explained by the fact that…
6 270、There is extensive evidence suggesting that…. play important roles in
271、We tested whether….. On the one hand, but we have found no evidence
that…..On the other hand,..
272、A combination of …… resulted in an unexpected synergy on PPAR_‐induced gene
expression. In the experiments, we used sequential treatment because we reasoned
that it probably represented a more physiological setting.
273、The principal finding of the present study is that…. The possible explanation
for….is ….
274、Several epidemiological studies and intervention trials have been performed
with…. and some of them showed that
275、For a long time, vitamin E was assumed to act by decreasing the oxidation of LDL,
a key step in atherosclerosis initiation
276、It is assumed that specific interaction of ….. with enzymes and proteins are at
the basis of its non‐antioxidant effects.
277、These interactions promise to reveal the biological properties of ….and allow
designing better strategies for the protection against atherosclerosis progression
278、….has been entrusted with therapeutic properties against cardiovascular disease
(CVD) for almost 60 years
279 、 Alternative non‐antioxidant mechanisms of…..action have been recently
suggested, such as its involvement in cellular signaling…..
280、In humans, although epidemiological studies have given indications that ….
protects against atherosclerosis progression, clinical intervention trials have reported
contradictory results. The reasons of this ambiguity may possibly lay on the enrollment
in clinical studies of patients with already manifested atherosclerotic lesions or
increased risk of cardiovascular disease
281、…..inconsistent, but as described below, several reasons can be postulated that…
282、An accurate interpretation needs to take into account the modality of selection
7 for enrollment, the geographical area of selected subjects connected to the diet
differences, the stage of the disease, the chosen markers, the dosage and the type of
vitamin E used in each of these trials
283 、 These data may allow us to presume the involvement of alternative
nonantioxidant mechanisms for the anti‐atherosclerotic effect of TSN.
284、The different type and dose of tocopherol supplements administered within the
trials can also explain the incongruence between their results.
285、Yet, it has not been very clearly established whether….
286、The ability of in vitro LDL oxidation has been
unequivocally proved
287、Because it has a central role within the inflammatory response, attempts have
been made to therapeutically regulate the activity of NF‐
suggest that….
288、This hypothesis is sustained by the fact that…..
289、……be inversely associated with……
290、promising results on the progression of As and on the incidence of vascular
diseases have been reported by…..
291、the results from …..have provided good evidence of benefit…….provide further
evidence about the effects of ……on…..
292、the results of …..indicate that……daily supplementation with….is safe. But,
although……no significant benefits were observed among the high risk individuals that
were studied.
293、these results effectively rule out the possibility that…..
294、Factors to consider in interpreting these findings include the population studied,
the vitamin dosages (and combination) tested, and the duration of treatment and
follow‐up.
295、likewise, similarly…..
8 296、no significant improvements in…were observed with…..(albeit a relatively low
dose)…..either alone or in combination with….
297、Hence, the available evidence from observational studies of different antioxidant
regimens does not suggest….
298、But, there was no suggestion that beneficial effects were beginning to emerge
even during…..
299、Based on the presumption that the likelihood of benefit outweighs any low
probability of harm, daily supplementation with…..
300、But, despite assessing the combined effects of…. The Study has not been able to
demonstrate any benefits from such supplementation.
sci谜案集第六部 sci是什么 sci二区和三区区别
