SCI写作高大上句型1000例—901‐1000
901、Our studies suggest the possibility that fish oil–rich diets currently recommended
for treatment of atherosclerotic CVD42,43 could be particularly beneficial for CVD in
obesity and type 2 diabetes.
902、Additional studies will be needed however to determine the exact mechanisms
responsible for the associations between…and…
903、Furthermore, these findings suggest a novel mechanism by which the central
nervous system could potentially influence atherogenesis,。。
904、One of special interest to TS anti–atherogenicity is the finding that…
905、By contrast, in the atherosclerotic ApoE‐KO mice (that are under high oxidative
stress), absence of the a7nAchr increased the macrophage uptake of ‘‘native” LDL, but
not that of ‘‘oxidized” LDL. While these results appear to be paradoxical, the
discrepancy may be explained by peculiarities of the assays used to measure‘‘native”
and ‘‘oxidized” LDL uptake.
906、Finally, several limitations to the present study should be considered. First, the
experiments were conducted in a small number of animals, and even though all mice
in each group demonstrated a very similar atherogenic pattern, we may have lacked
statistical power to detect differences in some of our outcome variables. Second,
while the changes we observed in macrophage phenotype suggest that thea7nAchr
has an atheroprotective function, this needs to be directly tested by measuring
atherosclerosis lesion size in a larger group of animals, which we are currently
planning. Third, additional studies are needed to assess mechanisms for the
potentially atheroprotective effects that were noted, particularly to determine if the
differences in macrophage phenotype are directly mediated by the a7nAchr, or
indirectly mediated via its well established effects on macrophage inflammatory
cytokine production
907、In summary, we demonstrated that a clear feature of foam cell formation, and
1 a hallmark of early atherosclerosis development. These findings suggest that means
to increase the expression and activation of the a7nAchr could have therapeutic
potential.
908、Indeed, there is a large body of evidence that…. In fact, recent evidence suggests
that…. In parallel, there is strong evidence that…Therefore, we reasoned in the
present study that….
909、It has previously been demonstrated that….
910、Studies to assess the efficacy of …is currently underway in our lab, and initial
results seem promising. What remains to be established is whether ….reduce
vulnerable plaque formation in humans and, ultimately the incidence of heart attack
and stroke.
911、The results from this pre‐clinical trial provide compelling evidence that inhibition
of…block the development of unstable plaques by reducing the generation of
proinflammatory cytokines.
912、An unexpected finding of this study was….Further studies are needed to
determine whether…in this experimental model.
913、These histological observations were associated with reduced ….abundance and
proinflammatory gene expression in lesions of tan‐treated pigs.
914、Despite the accumulating circumstantial evidence pointing to a role of ….as a
culprit in unstable plaque formation, definitive proof has been lacking.
915、oxLDL is thought to play a key role in the pathogenesis of atherosclerosis. One
possible mechanism involves….This study was conducted to define the mechanism by
which oxldl increase….in macrophage.
916 、 It has been suggested that….There are no reports that address
whether…..Limited information is available regarding the signaling pathways involved
in….secretion by….XXX have shown a potential role for….
917、The objectives of the pesent study were to determine how…affect… and to define
2 the signal transduction pathways involved in enhancement of ….expression by.
918、These results demonstrate a dose‐dependent increase in…and are in agreement
with several previous reports in different cell types. We also found that….This suggests
that….
919、Our findings with…is in line with recent results that shows…Our findings contrast
somewhat with the report of…et al, who proposed that….
920、Further studies are required to define the quantitative importance of…in VEGF
induction by oxLDL.
921、Our results also rule out an essential role for….The observed discrepancy
between our results and previous reports could be explained by the fact that,…
922、The clinical implication of….in atherogenesis is still under debate.
923、The regulatory mechanisms involved in increased…secretion in response to oxldl
have not been clearly dissected.
924、We found no evidence that….are involved.
925、Together, these findings prompted us totest whether pfn played a direct role in
atherosclerotic lesion formation. To this end, we。。。To test the consequences of
reduced pfn expression on atherosclerotic plaque formation,
926、Reperfusion therapy for myocardial infarction is hampered by detrimental
inflammatory responses partly via Toll‐like receptor (TLR) activation. Targeting TLR
signaling may optimize reperfusion therapy and enhance cell survival and heart
function after myocardial infarction. Here, we evaluated the role of TLR2 as a
therapeutic target using a novel monoclonal anti‐TLR2 antibody.
927、…experiments revealed that….is determined by…..
928、Compared with saline‐treated mice, anti‐TLR2–treated mice exhibited less
expansive remodeling (end‐diastolic volume 68.2±2.5 versus 76.8±3.5 µL; P=0.046)
and preserved systolic performance. Anti‐TLR2 treatment significantly reduced
neutrophil, macrophage, and T‐lymphocyte infiltration. Furthermore, tumor necrosis
3 factor‐, interleukin‐1, granulocyte macrophage colony‐stimulating factor, and
interleukin‐10 were significantly reduced, as were phosphorylated c‐jun N‐terminal
kinase, phosphorylated p38 mitogen‐activated protein kinase, and caspase 3/7 activity
levels.
929、Circulating TLR2 expression mediates myocardial ischemia/reperfusion injury.
Antagonizing TLR2 just 5 minutes before reperfusion reduces infarct size and preserves
cardiac function and geometry. Anti‐TLR2 therapy exerts its action by reducing
leukocyte influx, cytokine production, and proapoptotic signaling. Hence, monoclonal
anti‐TLR2 antibody is a potential candidate as an adjunctive for reperfusion therapy in
patients with myocardial infarction.
930、…is known to play a crucial role in the…The role of HDAC3 in mature endothelial
cells, however, is not well understood. Here, we investigated the function of HDAC3 in
preserving endothelial integrity in areas of disturbed blood flow
931 、 In line with these findings,…. led to a dramatic decrease in cell survival
accompanied by apoptosis in endothelial cells
932、Our findings demonstrated that HDAC3 serves as an essential prosurvival
molecule with a critical role in maintaining the endothelial integrity via Akt activation
and that severe atherosclerosis and vessel rupture in isografted vessels of
apolipoprotein E‐knockout mice occur when HDAC3 is knocked down.
933、Endothelial dysfunction is the initiating event of atherosclerosis. The expression
of connexin40 (Cx40), an endothelial gap junction protein, is decreased during
atherogenesis. In the present report, we sought to determine whether Cx40
contributes to the development of the disease.
934、Mice with ubiquitous deletion of Cx40 are hypertensive, a risk factor for
atherosclerosis. Consequently, we generated atherosclerosis‐susceptible mice with
endothelial‐specific deletion of Cx40 (Cx40del mice). Cx40del mice were indeed not
hypertensive. The progression of atherosclerosis was increased in Cx40del mice after
4 5 and 10 weeks of a high‐cholesterol diet, and spontaneous lesions were observed in
the aortic sinuses of young mice without such a diet. These lesions showed monocyte
infiltration into the intima, increased expression of vascular cell adhesion molecule‐1,
and decreased expression of the ecto‐enzyme CD73 in the endothelium. The
proinflammatory phenotype of Cx40del mice was confirmed in another model of
induced leukocyte recruitment from the lung microcirculation. Endothelial CD73 is
known to induce antiadhesion signaling via the production of adenosine. We found
that reducing Cx40 expression in vitro with small interfering RNA or antisense
decreased CD73 expression and activity and increased leukocyte adhesion to mouse
endothelial cells. These effects were reversed by an adenosine receptor agonist.
935、These data strongly suggest that IRFI005 can operate by a recycling mechanism
similar to the XXX
936、This study was undertaken to characterize the antioxidant activity of…
937、...gave contrasting/ conflicting results.
938 、 consistent with the previous results, our present study also
showed ….considering our experimental results with other report in which….it is
suggested that….might be a causative factor involved in the progress of
atherosclerosis.
939、The questions arises as to…As a possible answer, we focused on the expression
of….
940、Upon exposure of J774.A1 macrophages to HNE in the in vitro study, strikingly
increased expression of SR‐A protein with small degree of CD36 was evident with a
concomitant increase in endocytic uptake of oxLDL.
941、These findings are supported by other reports in which….
942、Moreover, SR‐Awas reportedly responsible for the majority of macrophage
uptake of modified LDL in a study using
943、These results were also supported by the report of Ishii et al. Future studies are
5 needed to determine the signal pathway how…..lead to the regulation of … and
subsequent …
944、Thus, it is suggested that HNE may be an important novel therapeutic target for
the prevention and treatment of atherosclerosis. Additionally, our study provides
evidence for the first time that…..
945、There is a paucity of data testing the effect of CsA on LDL oxidation.
946 、 This study provides evidence supporting the atheroprotective effect
of….Through…..activation/depression, …promotes RCT and limits foam cell formation
in THP‐1 macrophages. This is the first evidence that…Our results suggest that one
mechanism by which tan protects against cardiovascular mortality in patients with…is
through facilitation of cholesterol outflow from cells of the arterial wall.
947、but the relevance of triglyceride‐rich lipoproteins (TRLs) to atherogenesis
remains controversial.1 In part, this controversy stems from the fact that。。。。
948、Our findings suggest that EGCG and hesperetin may act as antiatherogenic agents
blocking oxidized LDL‐induced endothelial apoptosis via differential cellular apoptotic
machinery
949 、 The finding underscores the importance of Ang II in the regulation of
mitochondrial biogenesis and cardiac metabolomics, even in healthy hearts.
950、To further strengthen our in vivo reported findings and explore CRP‐mediated
events in depth, we exploited an in vivo rat sterile pouch model….
951、However, CRP failed to have any effect on TIMP‐1 production concomitant with
increased MMP‐9 activity in the present study, in agreement with the findings
reported by other investigators.
952、To conclude, in the present study, we make the novel observation that in vivo,
CRP enhances OxLDL uptake and cholesteryl ester accumulation and stimulates MMP‐
9 release, which could contribute to plaque rupture.
953、Thus, strategies aimed at decreasing CRP may prove to be beneficial in preventing
6 atherothrombotic events and reducing atherosclerosis‐related events.
954、Research in recent years has documented a specific role for the macrophage
transporters ATP‐binding cassette subfamilies A1 and G1 (ABCA1 and ABCG1) in
cholesterol efflux
955、These findings have stimulated efforts to target。。。
956 、 Despite strong evidence for an inverse association between high‐density
lipoprotein cholesterol (HDL‐C) levels and cardiovascular risk,1
successful therapeutic
strategies to target HDL have remained elusive
957、This outcome reinforced a growing consensus that。。。The careful mechanistic
assessment of HDL function has thus emerged as a potential way forward
958、…providingan explanation for the atheroprotective effects and identifyinga novel
mechanism by which FTY720 modulates signaling.
959、These findings suggest a potential role for….in the pathogenesis of coronary
atherosclerosis.
960、Our findings are supported by …et al who found prominent ….immunoreactivity
in atherosclerotic plaques of….
961、…induce SMC proliferation alone or in a synergistic fashion with oxlDL, a major
contributor to atherosclerosis.
962、These data support a role for…as a contributing factor in the pathophysiology of
atherosclerosis. To determine the pathological significance of ….in the etiology of
experimental atherosclerosis, we examined the effect of …in apoE KO mice fed a HFD.
963、These findings highlight an attractive therapeutic target for
964、The precise mechanisms underlying VSMC phenotypic modulation remain elusive.
Here we test the role of….
965、.. hasbeen well documented to play a critical role in many inflammatorydiseases.
However, the role of complement in the pathogenesis of abdominal aortic aneurysm,
which is considered an immune and inflammatory disease, remains obscure
7 966、Together, these results defined the protective role of CD59 and shed light on the
important pathogenic role of the membrane attack complex in abdominal aortic
aneurysm.
967、Angiopoietin‐2 Confers Atheroprotection in apoE–/– Mice by Inhibiting LDL
Oxidation
968、Despite a concerted effort by many laboratories, the critical subunits that
participate in vascular smooth muscle cell (VSMC) NADPH oxidase function have yet
to be elucidated.
969、Taken together, our study reveals IRAK‐1 as a novel component involved in the
generation of ROS induced by LPS.
970 、 Our findings establish for the first time that LPS‐mediated
PTK/phosphatidylinositol 3‐kinase/Rac/p38 pathways play a more important role than
pathways of…The findings also further elucidate the critical role of LPS‐mediated ROS
in signal transduction pathways. Our results suggest that…
971、but data about the specific dietary constituents involved and mechanisms
conferring cardioprotection are still sparse.
972、Oxidative modification of low‐density lipoprotein (LDL) plays a causative role in
the development of atherosclerosis
973、To provide specific evidence for a role of Syk….. To corroborate the results with
974、…tended to increase, but the difference was not statistically significant.
975 、 Peroxisome proliferator‐activated receptor‐γ (PPARγ) is a ligand‐activated
transcription factor of the nuclear hormone receptor superfamily. Increasing evidence
suggests that PPARγ is involved in the regulation of vascular function and blood
pressure in addition to its well recognized role in metabolism. Thiazolidinediones,
PPARγ agonists, lower blood pressure and have protective vascular effects through
largely unknown mechanisms. In contrast, loss‐of‐function dominant‐negative
mutations in human PPARγ cause insulin resistance and severe early onset
8 hypertension. Recent studies using genetically manipulated mouse models have
begun to specifically address the importance of PPARγ in the vasculature. In this
minireview, evidence for a protective role of PPARγ in the endothelium and vascular
smooth muscle, derived largely from studies of genetically manipulated mice, will be
discussed.
976、…. Previously we reported that…Here, we show that…These data identify a novel
and discrete mechanism of regulating HDAC4 levels and, subsequently, gene
expression.
977 、 It is presently unknown whether the endocannabinoid system exerts a
widespread effect on neuronal precursors from different neurogenic regions, and very
little is known about the signaling by which it regulates neuronal precursor
proliferation. Herein, we demonstrate the presence of…indicating that the
endocannabinoid system is physiologically involved in regulation of GCP proliferation
978、Adiponectin is an adipocyte‐derived, secreted protein that is implicated in
protection against a cluster ofrelated metabolic disorders
979、Adiponectin has been associated with antiinflammatory and antiatherogenic
properties; however, the direct involvement of adiponectin onthe atherogenic process
has not been studied.
980、NO is known to be an important effector molecule that has a broad spectrum of
physiological and pathophysiologic effects
981、It is noteworthy that the finding of the present study may shed light on the
pharmacological basis for the clinical application of traditional Chinese medicine in
treatment of atherosclerosis relevant to endothelial cell damage.
982、In summary, the present study indicates that the estrogen‐like effects of Tan IIA
are due, at least in part, to its ability to transactivate ERα or ERβ. Tan IIA exerts anti‐
inflammatory effects by inhibition of iNOS gene expression and NO production, as well
as inhibition of inflammatory cytokine (IL‐1β, IL‐6, and TNF‐α) expression via ER‐
9 dependent pathway. These findings provide new insights in understanding the
complex actions of Tan IIA in immune response and suggest that it could serve as a
potential selective estrogen receptor modulator (SERM) to treat inflammation‐
associated neurodegenerative and cardiovascular diseases without increasing the risk
of breast cancer.
983、Although numerous studies on the pharmacological actions of Tan IIA have been
demonstrated, the details of the mechanism of the actions still need to be determined
984、As a result, there is an increased interest in exploring the new therapeutic
potentials of Tan IIA. Previous investigations showed that…
985 、 BPS suppressed the pathogenesis and development of diabetes and its
complication, nephropathy, which was presumably accompanied by improving glucose
intolerance and insulin resistance in obese Zucker rats.
986 、 Despite strong evidence for an inverse association between high‐density
lipoprotein cholesterol (HDL‐C) levels and cardiovascular risk,1
successful therapeutic
strategies to target HDL have remained elusive.
987、This outcome reinforced a growing consensus that…. The careful mechanistic
assessment of HDL function has thus emerged as a potential way forward
988、XXX has been postulatedto play a major role in HDL‐mediated atheroprotection…
989、Researchin recent years has documented a specific role for …in cholesterol efflux
990、These findings have stimulated efforts to target the macrophage at the cellular
level as a means of enhancing overall RCT….
991、A potential therapeutic use of this system has only recently come within reach
through synthesis of。。。
992、When given concurrently with a high‐fat diet, this approach does not accurately
mimic a realistic therapeutic modality in humans
993、Inhibition of VSMC proliferation in vitro by PPAR ligands is an important
mechanism for their observed in vivo effect to inhibit neointima formation in rat
10 models of restenosis
994、More importantly, early clinical studies demonstrate that TRO administration
reduced intimal hyperplasia after coronary stent implantation. Data presented in this
study carry important implica‐tions for future PPARγ‐based pharmacology.
995、Vascular endothelium is emerging as a therapeutic target for atherosclerotic
macrovascular disease in diabetes
996、Most importantly, it has recently been demonstrated that troglitazone inhibits
the development of atherosclerotic lesions in male LDL receptor–deficient mice.
997、The present study demonstrates that troglitazone has multiple vascular actions
capable of influencing the progress of vascular disease; however, additional studies
and clinical trials are required to assess the long‐term therapeutic impact of
thiazolidinediones such as troglitazone, but now more likely pioglitazone and
rosiglitazone, on the progress of vascular disease in diabetes.
998、…have been extensively studies in animal models of atherosclerosis.
999、We next investigated….to further evaluate…to further address the mechanisms,
we instigated the production….plaque burden/lesion burden/plaque volume
1000、These observations provide direct evidence for that FXR is a key signaling
component in regulation of vascular osteogenic differentiation and, thus representing
a promising target forthe treatment of vascular calcification.
