SCI写作高大上句型1000例—701‐800
701 、 In addition to its role in…. accumulating evidence suggests that hypoxia
participates in the development of XXX
702、Despite the in vivo evidence suggesting that…. the role moderate hypoxic milieu
plays in vascular inflammation and atherogenesis remains obscure.
703、The present study used primary mouse peritoneal macrophages to test the
hypothesis that a physiologically relevant level of tanshinone II‐A nfluences
macrophage expression of atherosclerosis‐associated genes via activation of the Akt
and _‐catenin pathways.
704、XXX plays central roles in inflammatory ailments.
705、Interestingly, recent evidence suggests that…. Accumulating evidence has further
demonstrated that ….; ….also functions in various other fundamental biological and
pathological processes such as innate immunity and inflammation
706、Additionally, we demonstrate in human macrophages that …; …. et al recently
reported that….
707、The present study demonstrates that…. may further amplify the inflammatory
milieu. Our observations expand the mechanistic understanding of macrophage
activation and provide new insight into the pathogenesis of chronic inflammatory
diseases.
708、The present study demonstrates that Akt activation in human monocyte‐derived
macrophages by chronic moderate hypoxia causes inactivation of GSK‐3 and nuclear
accumulation of ‐catenin. Collectively, these studies indicate that Akt plays a pivotal
role in the proinflammatory phenotype of macrophages, providing a new mechanism
in macrophage biology,
709、Despite evidence for the role of Akt in ‐catenin accumulation…. could also
mediate these responses, a subject for future study.
710、Biological mechanisms underlying….differ.
1 711、Large‐scale clinical studies have demonstrated that simvastatin, an HMG‐CoA
reductase inhibitor, and losartan, an AT1 receptor blocker, prevent and retard the
progression of coronary heart disease.
712、The mechanisms of this benefit may relate to the ability of these therapies to
reduce
713、The present study is the first report demonstrating that….
714、This work lends support for developing immunization strategies to boost natural
antibody
protection and potentially limit atherosclerosis.
715、Overall, our data provide the first direct evidence that …
716、Interestingly, it is noteworthy that,,,a limitation of our study is that…
717、Taken together, these observations indicate that…..extend our observations
to….and suggest that alternations produced in…with combined therapy may have
functional significance.
718 、 However, several recent examples have dramatically underlined that
extrapolation of surrogate markers of AS to actual cardiovascular events is risky.
719、The present study extends our prior observations…The present results are
consistent with…..importantly, the benefit was derived primarily from….
720、The present study extends and complements these observations by focusing on
the relative….with
721 、 Boosting HDL‐C is a current strategy for preventing clinical events. We
hypothesized that….combined statin/tanshinone ii‐A therapy partially reverses…. Our
observations raised the possibility that….could provide insight into therapeutic
efficacy of anti‐AS interventions.
722 、 We hypothesized that combination therapy with a statin/Tanshinone, a
monomer isolated from traditional Chinese medicine‐Tanshen, would modify lipid
profile and plaque stability and these modifications might provide insight into its anti‐
2 AS and anti‐inflammatory properties.
723、To test this proposal, we use …to investigate the impact of intensive lipid
lowering with TS…our observations also indicate that combined therapy….
724、It is now widely appreciated that plaque rupture is an important component of
ACS, …in a dysfunctional state.
725、The article by… et al elucidate important potential mechanisms whereby OX‐LDL
contributes to cellular dysfunction via ER stress that is ultimately manifest in plaque
rupture.
726、In support of this concept, our investigation of the effects of…on…revealed
that….An important role of….has also been demonstrated in several diseases,
including…and…
727、Studies of…also support the relevance of A to B and C in advanced atherosclerotic
plaques, however, it is still unclear whether…has a role in plaque rupture.
728、Unfortunately, the absence of a suitable animal model that resembling human
atherosclerosis has greatly hindered the investigation of the molecular mechanisms
of plaque rupture and evaluation of the effects of plaque‐stabilizing agents in vivo
729、The findings in the present study underline the importance of …in….
730、There are several limitations to the present study…..can be used in future studies
to further our understanding of…..
731、Multiple mechanisms have been postulated for the development of diabetic
nephropathy, including…. oxidative stress, inflammation,and hemodynamic changes.
732、Therefore, multi‐targeted therapeutic interventions should be required for DN.
733、Recently, it has been reported that several herbs such as ….have multitargeted
athero‐protective effect in AS. In the present study, we demonstrated the multi‐
targeted renoprotective effects of Tanshinone IIA on AS
734、To the best of our knowledge, this is the first report showing that….
735、More evidence for this concept comes from many basic and clinical observations.
3 736、…play a fundamental role in plaque formation and stability.
737、As reported in previous studies,…
738、The excellent technical support of…is greatly appreciated. Part of this work will
be included in the doctoral thesis of….
739、It maybe mechanistically involved in the plaque disruption that produces ACS.
740 、 Although clinical appreciation of….has since increased significantly, the
mechanism by which…remains unclear.
741、Therefore, it is conceivable that….Insight that drawn from animal models
that….support this hypothesis.
742、A consensus emerges that these processes are in delicate balance and have
potentially opposing roles in plaque progression and destabilization.
743、…contribute a provocative article proposing a hitherto unappreciated role of HO‐
1‐CO pathway in atherogenesis.
744、The mechanism of niacin lowering of a…is uncertain but appears,unlikely to be
mediated by suppression of …..
745、This work, as well as related findings from other groups, provides a firm
pathophysiological foundation for potential involvement of Chlamydia in
atherosclerosis and local lipoprotein metabolism within atheroma.
746、We currently view the evidence for a role of Chlamydia in atherosclerosis as
follows:
747 、 A concordant data set suggests that….in agreement with Dr Shor’s
observations…Plausible biological mechanisms for a potentiation of atherogenesis
by…
748、We thank Dr Shor for his intriguing comments regarding the role of … in
atherosclerosis. We agree that Strong evidence links…and…In conclusion, we share Dr
Shor’s fascination with the possible role of Chlamydia pneumoniae in atherogenesis.
We believe that….
4 749、Over last decade, appreciation of the role of inflammation in atherosclerosis
has burgeoned.
750 、 Although…., substantial advances in basic and experimental science have
illuminated the role of inflammation and the underlying cellular and molecular
mechanisms that contribute to atherogenesis
751、Compelling evidence for the importance of inflammation and atherosclerosis at
both the basic and clinical level has evolved in parallel.
752 、 Accumulating data indicate that insights gained from the link between
inflammation and atherosclerosis can yield predictive and prognostic information of
considerable clinical utility.
753、The current notion that inflammation and immune response contribute to
atherogenesis has garnered increased interest….
754、Our current concepts recognize the biological attributes of the atheroma as key
determinants of its clinical significance. This review will weave together laboratory
and clinical advances to provide an update on inflammation in atherosclerosis.
755、During recent years, experiments in genetically altered mice have lent further
support to the hypothesis that …
756、In clinical studies, it was observed that…clinical intervention studies showed
that….
757、However, the mechanism by which this occurs is not clearly defined.
758、This is the first report to demonstrate that, in a model of atherosclerosis,….
759、This perception is fostered by a study evaluating de novo atherogenesis in
experimental murine atherosclerosis, which showed….
760 、 However, several large studies evaluating the role of…failed to show an
association between…and prevalence of AS, suggesting that…. Thus, the role
of…remains undefined…. From these data, we hypothesized that….
761、These results identify a new function of the coagulation system, resulting in
5 enhanced plaque stability during de novo atherogenesis.
762、Platelet aggregation plays a critical role in myocardial infarction and stroke;
however, the role of platelet secretion in atherosclerotic vascular disease is poorly
understood. Therefore, we examined the hypothesis that…
763、Previous studies have established that…. In confirmation of these findings, we
found that XXX
764、To examine the effect of..on…. Mice were placed on a high‐fat diet beginning at
6 weeks of age to accelerate the development of atherosclerotic lesions.
765、Microscopic examination confirmed that…. Consistent with this notion, we found
that…. and atherosclerotic remodeling were markedly attenuated in the injured
vessels from mice with…
766、In neointimal size and content of ‐actin–positive smooth muscle cells, CD45‐
positive leukocytes, and Mac‐3–positive macrophages.
767、It will be important to further elucidate these mechanisms and to explore the
potential utility of…. as a therapeutic target in atherothrombotic disease.
768、Based on these data, we have recently investigated whether… Our previous
findings have revealed a hitherto unknown …effect of …, suggesting a new direct role
of adipose tissue in the pathogenesis of…
769、Based on this initial work, we have further characterized…. Together, these
clinical and experimental data support a key role for…In the present study, we
investigated the role of…
770、Recent studies from animal models support a novel role for…More recently,…The
precise molecular mechanism of the cardiodepressive effect of …. is not yet
understood.
771、To address the potential role of… in atherogenesis, we first investigated the
expression…then studied the effect of…
772、... showed a more pronounced inflammatory profile in the vascular wall as
6 detected by q‐PCR
773、Experimental evidence on the role of CRP in atherogenesis and vascular disease
is mixed/controversial.
774、To evaluate the expression of PTX3 during atherogenesis, we performed a time‐
course experiment in ApoE‐KO mice fed a chow diet and investigated PTX3 mRNA and
protein expression in the aortas. In agreement,…
775 、 The most important finding of this study was the observed interaction
between…and…
776、THE mechanisms underlying the attenuation of AngII‐induced actions by STS
remains an area of considerable interest.
777、XXX play a potentiating role in the growth process by activating several signaling
pathways.
778、Another question arising from the present study is: Why dose…treatment fail to
suppress angII‐induced….in myocytes? One possibility is that/ one possible
explanation for this action is that….
779、The expression of….predominate over…expression level.
780、Because Ca is thought to be an important, the modulation of angII mediated
changes in…provides a rationale for the reversal of some angII effects by STS.
781、An increasing number of published studies are investigating the pleiotropic
effects of statins, with diverging results. These results stress the need for a larger
multicenter study to shed more light on this important mechanistic issue
782、We read with great interest the recent article by。。。
783、This investigation has resulted in several novel observations. First, to our
knowledge, our findings suggest for the first time in vivo that…Furthermore, our data
suggest that….
784、A critical assessment of the data gathered in this research would suggest that
the protective effects of…. were primarily attributed to the down‐regulation of….
7 785、TACE siRNA had no long‐term protective effect on hypertension in either SHRs
or Ang II–infused mice. However, we cannot exclude that TACE siRNA treatment could
have a short‐term or transient protective effect that was nonetheless insufficient to
prevent the development of hypertension in both SHRs and Ang II‐infused mice.
786、Because of the complexity of the effects of TACE inhibition on the transcription
of multiple genes, dedicated studies are warranted to further dissect the mechanism
of the short‐term roles of TACE in the regulation of blood pressure of hypertension
787、However, our long‐term data are consistent with previous research showing that
the pharmacological inhibition of…does not decrease systolic blood pressure in Ang
II–infused mice. Our long‐term data are also in agreement with previous research
showing that pharmacological blockade…does not protect mice from agonist‐induced
hypertension.
788、Previous studies have found that…. Recently, a novel role for ADAM‐12 was
reported in facilitating activation of transforming growth factor ‐ signaling through
Smads, which is the main pathway mediating the development of agonist‐induced
fibrosis.
789、Similarly, MMP‐2 has been shown to promote…thus facilitating Smad signaling.
790、Previous work also showed that…. Although the potential involvement of TACE
in cardiac hypertrophy and fibrosis is suggested by previous research. TACE
involvement in these processes has not been demonstrated in vivo.
791、This study has identified novel and significant effects of TACE siRNA on both
cardiac hypertrophy and fibrosis in vivo. Our observations provide the first in vivo
evidence that TACE expression regulates the development of cardiac hypertrophy and
fibrosis and, as such, substantially expands previous research. Taking our findings
together with previous investigations, we suggest that an overabundance of
vasoconstrictive agonists (as occurs in hypertensive disorders) could
posttranscriptionally enhance the activity of…
8 792、Despite extensive research, an interaction among the pathways of TACE, ADAM‐
12, and MMP‐2 has never been identified. Therefore, a novel finding of this research
has been the observation that baseline gene expression levels of TACE and ADAM‐12
are transcriptionally connected, although further research is necessary to dissect the
transcriptional pathways linking these metalloproteinases. Together with previously
reported….
793、This notion is supported by our studies both in mice with agonistinduced cardiac
hypertrophy and in SHRs, a model where cardiac hypertrophy is likely signaled by
multiple agonists
794、These current findings have therapeutic potential in hypertensive heart disease.
Our data suggest that…
795、This is consistent with the observation by..et al that…. In addition, recent data
from…et al. , coupled with….is largely responsible for enhanced…..
796、These observations are in line with our previous studies demonstrating that …It
remains to be elucidated in which…
797、Multiple mechanisms have been postulated for…So it is also plausible that the
beneficial effect of tanshinone II‐A in the treatment of cardiac fibrosis could relate to
the suppression of angII mediated cellular response.
798、A possible explanation for the results is that…. little information exists whether
the same applies to the latter, ie, whether
799、There is extensive evidence that…consistently accompanies….
800、This has deleterious consequences on the severity of hypertension itself,
because….
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