SCI写作高大上句型1000例—301‐400
301、But, in light of the unpromising results during XXX
302、 Hence, continued recommendation of supplementation with such vitamins is
difficult to justify. Instead, the main emphasis should be on those treatments (eg,
aspirin, statins, angiotensin‐converting‐enzyme inhibitors, _‐blockers, and
antihypertensive therapy) that are definitely known to prevent heart attacks, strokes,
and other adverse outcomes.
303、The lack of benefit of antioxidant vitamins in several large randomised trials
contradicts the claims from observational studies that suggested protection against
cardiovascular disease
304、These findings emphasise the need to generally view claims of treatment benefit
from observational studies with considerable scepticism, unless confirmed by large
well‐designed randomised trials.
305 、 Therefore, the potential gains from the combination of currently known
preventive strategies are large. Given that over 80% of cardiovascular disease occurs
in developing countries, a priority is to make these interventions affordable,
accessible, and convenient (perhaps even a combination pill). Ensuring that patients
worldwide receive these treatments will lead to substantial clinical and public‐health
benefits.
306、…..study show the lack of efficacy of VE in preventing the vascular complications….
were underrepresented in the current study
307、…great strides have been made in the use of various pharmacologic interventions
for the treatment of patients with cardiovascular disease.
308、Their findings demonstrate a significant benefit associated with the….. , adding
to the growing body of evidence that supports instituting drug therapy that targets…
309 、 This study presents intriguing information in…. First, it demonstrates
that….because of ……., it is important to note that……
1 310 、 Because oxidative processes are important in the development of
atherosclerosis, …supplementation has been proposed for the treatment and
prevention of coronary disease.
311、….supplementation in conjunction with …. treatment was associated with a
reduced rate of progression of coronary‐artery lesions
312、However, enthusiasm for the use of supplemental vitamin E has recently
decreased in the light of other trials demonstrating no beneficial effect. Also, the use
of……may be deleterious.
313、In the light of previous trials, a limitation of this study is its use of a mixed regimen
of a
314、Although antioxidant therapy does not appear to be useful in patients with …..,
the possibility that it may have a benefit in other patients with cardiovascular disease
has not been excluded.
315、Although intriguing, these results cannot be extrapolated to other populations,
Primary prevention settings, or other lipid‐altering combinations, especially in the
light of the recent concern about the side effects of statins.
316、However, these data demonstrate the importance of targeting…. and support
the conclusion that a larger study is warranted.
317、Although this study cannot completely refute claims that other combinations of
antioxidant treatments are useful in distinct populations, the findings add to the
growing body of evidence that certain supplemental antioxidant regimens have
limited benefit in patients with cardiovascular disease.
318、Our findings in vitro and in vivo support the interpretation that..
319、Dissection of mechanisms of Chinese medicinal formula …..as an effective
treatment for…
320、To enhance therapeutic efficacy and reduce adverse effects, practitioners of
traditional Chinese medicine (TCM) prescribe a combination of….. based on clinical
2 Experience
321、….but the working mechanisms of most remain unknown.
322、In trying to address the possible beneficial effects of….with current biomedical
approaches, we use ….., which has been proven to be very effective in treating….
323、Here, we report that the ATV in combination with. TSN yields synergy in the
treatment of ApoE deficient atherosclerosis‐prone model in vivo and in macrophage
foam cell formation in vitro.
324、….caused intensified….and enhanced through hitting multiple targets compared
with the effect of monotherapy. Furthermore, …..intensified the expression of ……and
facilitate …..which in turn enhances….and therapeutic efficacy. Our data also
indicate….as….
325、We therefore suggest that dissecting the mode of action of clinically effective
TCM at the molecular, cellular, and organism levels may be a good strategy in
exploring the value of traditional medicine and explore the combination therapy
between TCM and western medicine.
326、Increasing evidence demonstrates that, in treating illnesses, including coronary
heart disease ( literature) cancer (1) and HIV/AIDS (2), treatment regimens containing
multiple drugs with distinct but related mechanisms can usually amplify the
therapeutic efficacies of each agent, leading to maximal therapeutic efficacy with
minimal adverse effects.
327、whereas precise mechanisms of formulae remain to be addressed by using
molecular approaches…
328、The literature documents the antitumor activity….
329、These results not only demonstrate the clinical efficacy of, but also suggest the
possible synergistic effects….. warranting the mechanistic exploration of this formula.
330、In trying to approach the rationale of formula design in TCM, here we use the
treatment of APL with RIF as a working model. efficacies and mechanisms of ATI
3 combination on APL were tested in vivo and in vitro.
331、In Vivo Therapeutic Efficacies of ….on a Murine AS Model.
332、In the past few years, the pharmaceutical industry has seen a shift from the
search for ‘‘magic bullets’’ that specifically target a single disease‐causing molecule to
the pursuit of combination therapies that comprise more than one active ingredient
333、One example is RIF, whose efficacies in treating APL have been well established
recently…..
334、In this study, we find that, in a murine AS model, combined use of the active
components of RIF, namely A, T, and I, significantly……
335、These results clearly show that components of RIF exert effects of mutual
reinforcement. However, ATI does not show an intensified adverse effect in the APL
murine model, as revealed by change in body weight, consistent with the safety of RIF
observed in the clinic. These observations are in agreement with the rationality of the
formula: mutual reinforcement of the compounds and reduction of adverse effects.
336、A large body of evidence indicates that ….. is the causative……
337、In this study, the ATI combination is found to be able to act on some key
transcription factors.
338、Finally, it is worth pointing out that, in the principle of designing a formula in
TCM,….
339、It may be an interesting observation in this work that
340、This phenomenon not only suggests that ……but also indicates that formulae
might exert therapeutic effects through mechanisms beyond each component.
341、Of note, in untreated….. These results suggest that AQP9 mediates, to a
significant extent, the therapeutic effects of …, and that …… might assist ….. in the
formula through modulating this key transporter.
342、…attenuate/ slow/ retard the progression of coronary AS
343、In the light of…..a limitation of the study is the use of ….rather than….
4 344、As compared with lipid‐altering therapy alone, the combined use of lipid‐altering
and …..therapy in the study by Brown et al. led to surprising results.
345、Previously, it was shown that….the mechanisms responsible for these changes
are not fully/ completely understood.
346、The protective increase in HDL2 with simvastatin plus niacin was attenuated by
concurrent therapy with antioxidants.
347、Simvastatin plus TsnII‐A provides marked clinical and experimental measurable
benefits in patients with coronary disease and in ApoE deficient As‐prone models. The
use of antioxidant vitamins in this setting must be questioned.
348、We undertook the present study to test the hypothesis that lipid‐altering and
antioxidant therapy provide independent and additive benefits in patients with
coronary artery disease and ApoE deficient mice.
349、differences are non‐significant within…..unless otherwise indicated/ specified.
350 、 In general, the treatment effects observed with respect to the primary
angiographic end point were confirmed for…… and were supported by the results
for ……..
351、There was only a trend (P=0.16 for the comparison with vehicle control) toward
a slowing of the progression of atherosclerosis, and there was minimal reduction in
the rate of clinical events.
352、Contrary to the hypothesis that antioxidants might provide the greatest benefit
in early lesions, they had no effect on
353、These findings concur with the results of four large negative trials of vitamins.
354、The greater‐than‐expected clinical and angiographically measurable benefits of
simvastatin plus niacin may, in part, be due to a proposed dual therapeutic pathway:
statins principally reduce the number of LDL particles; niacin principally increases
HDL2 levels and the buoyancy of LDL particles by diminishing hepatic lipase activity,33
one determinant of low HDL2 levels.
5 355、Surprisingly, when antioxidants were combined with simvastatin and niacin,
arterial and clinical benefits tended to diminish as compared with
356、The observed reduction of 60 to 90 percent in the rate of major coronary events
with combination simvastatin–niacin therapy, if confirmed, would represent a
substantial advance over current practice.
357、It is important to distinguish these results and those of other trials of antioxidants,
from the prevailing view that the oxidation of LDL contributes in an important,
although not a unique, way to atherogenesis.
358、Unless more compelling evidence appears, we see little justification for the use
of antioxidant vitamins for the prevention of cardiovascular events, particularly since
they lower….. and interfere with ……effects of concomitant lipid‐altering therapy.
359、Therefore, in the present study, to clarify how….activity is regulated by oxidized
LDL, we examined the effects of cholesterol feeding and simvastatin treatment
on ….activity and … concentrations in rabbits.
360、These results clearly indicate that…….However, ,…..treatment did not completely
reverse the effect of….on…..
361、This agrees with the finding of …. et al. who showed that
362、This finding agrees with the general knowledge that
363、Further clinical investigations are needed to evaluate whether or not
364、the findings in our study support the notion that……
365、therapeutic modulation of its activation could be of interest in pathological
conditions…..
366、among….are of particular importance…….
367、Taken together, these results suggest that ….
368、However, the exact mechanism still requires further study. Our study provide an
explanation of the relationship between the anti‐inflammatory effects and the anti‐
AS effect of TsnII_A, which is valuable for understanding the mechanism of Danshen
6 in Cardio‐protection.
369、…were partially attenuated….
370、Treatment of ….cells with 10um Tanshinone attenuated ….induced increases in….
371、However, there is no information concerning the mechanism for tanshinone‐I‐
induced reductions in hypertrophy of cardiomyocytes and fibrosis of cardiac
fibroblasts.
372、The primary mechanism of this protection appears to be in lowering blood
pressure. However, other mechanisms are also probably involved including…..
373、It may be that multiple mechanisms must be exploited simultaneously in order
to ameliorate…..
374、Detrimental, deleterious; attenuate, improve, ameliorate, stabilize; inhibit, limit
375、The aim of this study was to investigate the effect of
376、Statins reduce inflammation and disease activity in RA patients, but whether this
is due to pleiotropism or cholesterol lowering per se is unclear.
377、The available results from …..does not provide credible evidence that….
378 、 Epidemiologic and genetic studies have identified risk factors for the
development of ……, and experimental work has elucidated the cellular mechanisms
involved in disease progression, many of which resemble atherosclerosis. One
interpretation of these findings is that
379、The effect of….has been assessed in several…..Most studies have suggested a
beneficial effect of ….whereas one study did not find any effect of …..therapy on the
progression of…..
380、The study was designed to study the effects of intensive cholesterol lowering
with the use of…..and…..and….
381、The findings of ……group an compared with placebo controlled group, was
unexpected and requires further exploration in ongoing and future studies…..
382、It remains to be determined, however, whether these lipid‐independent effects
7 of statins contribute to the outcome benefits of statin therapy.
383、….but its role in….. remains incompletely understood
384、We therefore measured….. mmunoblot and immunohistochemistry techniques
revealed that….. To evaluate the impact of…. were generated….. Confocal and
immunoelectron microscopy revealed……predominantly localized to….. represents an
important therapeutic target…
385、….but the clinical benefits of……. therapy have not been demonstrated.
386、Preliminary studies of ….. therapy in coronary artery disease have shown a
decreased..
387、The objective of the present study was to identify
388、The present study suggests that ……could be a valuable tool to define therapeutic
strategies in ……
389 、 ……although the mechanisms culminating in these divergent disease
manifestations remain poorly understood
390、The present study defines a novel pathway in which…..
391、Diuretics are recommended as first‐line agents for the treatment of hypertension.
392、…therefore represents an effective option for the long‐term treatment of
essential hypertension….
393、Taken together, our results clearly demonstrate that prevention of the activation
of NF‐kappaB by PDTC reduces the development of…
394、Therefore, inhibition of NF‐kappaB may represent a novel approach for the
therapy of inflammation……
395、It is generally believed that….is influenced by a broad set of cardiovascular risk
factors….a broad spectrum of……It is well established that…
396 、 Evidence to strengthen this concept comes from the elegant study by
Zhang …The authors characterized…and determined the impact of….
397、Thus, it is conceivable that most of the effects observed in the present study are
8 mediated by….
398、The underlying mechanisms of how SIRT1 controls eNOS expression are, however,
still Uncertain..
399、In the light of these beneficial effects, it could be speculated that these
compounds might also be of value as a potential anti‐atherosclerotic therapy.
400、The objective of the present study was to identify and determine the prognostic
importance of……
sci谜案集第六部 sci是什么 sci二区和三区区别
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