SCI写作高大上句型1000例—401‐500
401、Although a multitude of mechanisms have been proposed, there are no studies
evaluating the impact of……
402、…. has previously been demonstrated to be required for……
403、the role of ….underlying……remain to be defined…
404、Finally, we provide evidence that these observations are applicable in vivo by
demonstrating…..
405、With refinement in….methodology, it has been possible to…
406、Several attempts have been made to….
407、This report presents observation…..
408、to study the cellular mechanisms influencing……
409、XXX provide a useful in vitro system to study the cellular mechanisms involved
in
410、..has limited their usefulness for in vitro studies of ……
411、this in vitro model system may be especially useful for studying the cellular
mechanisms for ….action in ….as well as identifying……
412、to address this concern,……
413、We demonstrate for the first time that…... These therapeutic effects were
mediated by……. These findings suggest the……..could represent an innovative
therapeutic option for treating diabetic neuropathy
414、...is an increasingly recognized phenomenon in…. Recently, reports have been
published that……It is unclear whether……. We sought to determine the relationship
between……We hypothesized that…..
415、Further research is needed to define….
416、The impact of …….on….is unclear. The objective of this study was to evaluate the
incremental effect of……
417、…..has been deemed……However, this …….event appears to be under‐recognized
1 and is worth being investigated further.
419、with regard to…..there is already ample evidence for the existence of…..
420、It is an attractive hypothesis that…..
421、This implies that…..could slow the development of….through complementary
mechanisms.
422、although data are accumulating to show that……..
423、The data acquired from these studies might give insight into achieving
424、The successful demonstration of…. encourages us to propose that…. The
remaining challenge is to establish a protocol to generate….
425、…has emerged as a powerful tool to study aspects of….
426、Efforts in our laboratory investigating the….. With little or no data to indicate
which molecules may be important in…..
427 、 To circumvent these difficulties some studies have eschewed whole cell
proteomics, employing a more focused approach…..
428、We have undertaken…. In support of this effort we have devised a novel
approach to generate…
429、To overcome this constraint…. To further examine the utility of this approach,
430、These observations provide strong evidence for cross‐talk between….and…..
431、There is evidence from experimental and animal studies for an interaction
between….and….in atherogenesis.
432、based on these considerations,
433、Our previous studies have shown that…..This study was designed to examine the
regulation by oxLDL of the expression of…..in HCAEC.
434、Incubation/pretreatment of…..cells with….for…hours increase the expression
of…(mRNA and protein) in a concentration and time‐dependent manner with
maximal expression at….
435、A number of investigators have shown that…..the effects of OxLDL in vascular
2 cells are mediated by….
436、Previous studies from our lab have shown that….others have shown that
inhibition of…in….blocked the effects of oxldl.
437、Although…., there is little information on its association with……
438、A statistically significantly interaction between…and…suggested that…
439、In analysis, there is evidence of linear associations between…and….
A linear increase of …. Was observed
440、There are limited data on…
441、Diabetes increases the morbidity/mortality of ….disease, but the underlying
mechanisms are incompletely understood.
442、….. but whether AMPK is cardioprotective or a central mediator of adiponectin
cardioprotection in vivo remains unknown.
443 、 Collectively, our results demonstrated that AMPK deficiency significantly
increases MI/R injury in vivo but has minimal effect on the antioxidative/antinitrative
protection of adiponectin.
444、however, the mechanism of this observation is not fully clarified.
445 、 The present study indicates that extracellular nucleotide–mediated eNOS
phosphorylation is calcium and protein kinase C dependent. This newly identified
signaling pathway opens new therapeutic avenues for the treatment of endothelial
dysfunction.
446、To elucidate the signaling pathway leading to…….cells were treated with several
drugs, including ………, in the presence or absence of selective inhibitors.
447、…..have no overall effect on the incidence of…..CHD events In women with
established…
448、Coronary outcomes were assessed by….. The effect of raloxifene on the incidence
of coronary events differed significantly by age.
449、….. but its clinical utility is uncertain. Essentially no reclassification improvement
3 was found with the addition of….. result in a statistically significant improvement in
the c‐index
450、The present analysis was conducted to validate the association between…and…
no significant associations between…and….was observed….
451 、 We sought to assess whether associations exist between…and….. Similar
reductions were seen…. remained sustained…..
452、The present study was performed to determine whether oxidative stress could
mediate…
453、…elicited markedly greater reductions in…..
454、The influences of antiplatelet therapy discontinuation on the risk of stent
thrombosis and long‐term clinical outcomes after drug‐eluting stent implantation have
not yet been addressed adequately.
455、…. did not suggest an apparent clinical benefit of….
456、Flow‐mediated dilatation testing provides an integrated vascular measure that
may aid the prediction of structural disease evolution and represents a potential short‐
to intermediate‐term outcome measure for evaluation of preventive treatment
strategies.
457、…increased significantly…. although the increment was much attenuated in….
458、May therefore provide a missing link between….and….
459、Taken collectively, specifically, mechanistically, importantly, more recently
Interestingly, Intriguingly, strikingly,
460、to further establish a link between….and…… we further determined….
461、cells are treated concomitantly with….and…..
462、We previously reported repression of….in…cells after treatment with…. This
prompted our interest to study…..It is of considerable interest /importance that….
463、….efficiently and specifically/selectively reduce….
464、to put these results into perspective, previous reports by….investigators have
4 provided convincing data supporting a role for….in the generation of foam cell and the
development of AS.
465 、 these data are particularly strong for….furthermore, a recent study in
which….demonstrated that….
466、It is conceivable that…../ conceivably,
467、despite the robustness of the observation that….a number of issues need to be
considered to interpret these data.
468、Interestingly, no significant differences in ….were observed between….
469、There is yet another important conceptual idea that needs to be addressed.
470、In this latter scenario, /in the context of AS,
471、Despite…it is not clear why the study from ….yields conclusions different from
those of other investigators.
472、the argument against this hypothesis is that,
473、the observed benefits have generally been attributed to the lowering of….
474、alternatively,
475、There are at least three possible explanations for the absence of an incremental
reduction in…in mice receiving…:
476、lead to a plethora of lipid independent effects involving
477、however, several facts argue against the concept that ….induced lowering of LDL‐
C does not produce additional vascular benefit beyond that of statins.
478、These close relationship between …..and cardiovascular risk has subsequently
been corroborated in several other studies.
479、This finding is further supported by the observation that…
480、On the basis of this information…also in view of….
as confirmed by…. as exemplified by…./equally
481、the treatment of patients with…has witnessed profound changes. Currently, the
majority of patients are treated with…
482、Thus, it is not unexpected that….in our study was lower than that observed
in …and in most other previous lipid‐modifying trials, with the exception of…
483、In further support of the influence of previous statin therapy,…a finding that
contrasts with the…
484、these data raised the possibility that…
485、the reason for the failure to observe an incremental effect on…despite a
reduction in levels of LDL‐C remains unknown.
486、a minor and non‐significant suppression (5%‐10% relative to control) of…protein
after incubation with…was found.
487、our data indicate that…We (present study) and others have shown that….
488、These observations mirror the data obtained from…this study provide the first
set of data on…..
489、…significantly suppressed…..greatly reduced…..markedly diminished….
490、appears to play crucial roles in atherosclerotic plaque rupture. We previously
reported that….are elevated in….are prominently expressed in atherosclerotic leisions.
491、The in vivo findings are consistent with results obtained ex vivo…
492、XXX of note/ it would be interesting to note that/……..
493 、 The current in vivo findings linking..to….support the observation that.
Elevated….resulted in….
495、Previous experiments performed in….mice, demonstrated that…..as evidenced
by….
495、confirming in vitro findings with in vivo results will no doubt further elucidate
the pathological role of …in vascular diseases.
496、have become part of clinical armamentarium in the treatment of cardiovascular
disease.
497、Treatment of….cells with….led to activation of inflammatory genes including…
498 、 The inductions of these genes induced by….was LOX‐1 dependent as
6 demonstrated by their attenuations in cells transfected with LOX‐1siRNA.
499、Our study identifies and characterize the direct interaction between..and… and
suggest….
500、These results together with our preliminary observations that….suggest a role
of….in the regulation of vascular Lox‐1 in…..
sci谜案集第六部 sci是什么 sci二区和三区区别
